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FDA Recommended Potent Drugs against Covid-19: Insight through Molecular Docking
Pomila
Pages: 1-21 | First Published: 05 Sep 2022
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Abstract
Human Coronavirus (COVID-19) is a worldwide pandemic of 2019-20 that was emerged in China in December, 2019. More than 37,000deaths with7, 84, 440confirmed cases has been reported from around 200 different countries has been reported till now and the number is increasing every second. The spread is said to be throughhuman to human transmission via close contact or respiratory droplets produced when people cough or sneeze. No treatment for the illness has been approved yet. The urgent need is to find solution to this growing problem that has affected the whole mankind. World Health Organisation (WHO) as well as US Food and Drug Administration (FDA) arecontinuously working to find the solution. In the same line they have proposed many potent drugs that may have efficiency against the newly emerged viral infection. To supportthe efforts the present study is designed to carry out the in silicoanalysis viz. Docking studiesof around 16drugs recently recommended by US FDA by observing the interaction of test molecules with SARS proteinase.
Keywords: COVID-19,Coronavirus, Docking studies, Auto-Dock, SARS proteinase inhibition, FDA, Potent Drugs

References

1. I.I. Bogoch, A. Watts, A. Thomas-Bachli, C. Huber, M.U.G. Kraemer, K. Khan,Pneumonia of unknown etiology in Wuhan, China: Potential for internationalspread via commercial air travel, Journal of Travel Medicine (2020).
2. D.S. Hui, I.E. Azhar, T.A. Madani, F. Ntoumi, R. Kock, O. Dar, et al., The continuing2019-nCoV epidemic threat of novel coronaviruses to global health—the latest2019 novel coronavirus outbreak in Wuhan, China, International Journal ofInfectious Diseases 91 (2020) 264–266.
3. https://edition.cnn.com/interactive/2020/health/coronavirus-maps-and-cases/
4. A.O. Adedeji, S.G. Sarafianos, Antiviral drugs specific for coronavirusesin preclinical development. Current Opinionin Virology8 (2014) 45–53. doi:10.1016/j.coviro.2014.06.002.
5. P.A. Rota, M.S. Oberste, S.S. Monroe, W.A. Nix, R. Campagnoli, J.P. Icenogle, et al. Characterization of a novel coronavirus associated with severeacute respiratory syndrome. Science. 300 (2003) 1394–9. doi:10.1126/science.1085952.
6. A. Berger, C.Drosten, H.W. Doerr, M. Sturmer, W. Preiser, Severe acute respiratorysyndrome (SARS)–paradigm of an emerging viral infection. Journal ofClinical Virology29(1) (2004) 13–22.
7. W. Liang, M.L. McLaws, M. Liu, J. Mi, D.K. Chan, Hindsight: a re-analysisof the severe acute respiratory syndrome outbreak in Beijing. PublicHealth. 121(10) (2007) 725–33. doi: 10.1016/j.puhe.2007.02.023.
8. S. Shigeta, T. Yamase, Current status of anti-SARS agents. AntiviralChemistry & Chemotherapy16(1) (2005) 23–31. doi: 10.1177/095632020501600103.
9. P.K. Cheng, D.A. Wong, L.K. Tong, S.M. Ip, A.C. Lo, C.S. Lau, et al. Viralshedding patterns of coronavirus in patients with probable severeacute respiratory syndrome. Lancet. 363(9422) (2004) 1699–700. doi:10.1016/S0140-6736(04)16255-7.
10. H.A. Dwosh, H.H. Hong, D. Austgarden, S. Herman, R. Schabas, Identificationnd containment of an outbreak of SARS in a community hospital.Can Med Assoc J. 168(11): (2003) 1415–20.
11. Zhang XW, Yap YL. Exploring the binding mechanism of the mainproteinase in SARS-associated coronavirus and its implication toanti-SARS drug design. Bioorg Med Chem. 2004;12(9):2219–23. doi:10.1016/j.bmc.2004.02.015.
12. Groneberg DA, Hilgenfeld R, Zabel P. Molecular mechanisms of severeacute respiratory syndrome (SARS). Respir Res. 2005;6:8. doi:10.1186/1465-9921-6-8.
13. Lin PY, Chou CY, Chang HC, Hsu WC, Chang GG. Correlation betweendissociation and catalysis of SARS-CoV main protease. Arch BiochemBiophys. 2008;472(1):34–42. doi: 10.1016/j.abb.2008.01.023.
14. Jacobs J, Grum-Tokars V, Zhou Y, Turlington M, Saldanha SA, Chase P, etl. Discovery, synthesis, and structure-based optimization of a seriesof N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188)as potent noncovalent small molecule inhibitors of the severe acuterespiratory syndrome coronavirus (SARS-CoV) 3CL protease. J MedChem. 2013;56(2):534–46. doi: 10.1021/jm301580n.
15. www.who.int
16. M.R. Dayer, S. Taleb-Gassabi, M.S. Dayer, Lopinavir; A Potent Drug against Coronavirus Infection: Insight fromMolecular Docking Study. Arch Clin Infect Dis. 12(4) (2017) 1-7.
17. (http://www.rcsb.org/pdb)

18. S.M.D. Rizvi,S. Shakil, M. Haneef, A simple click by click protocol to perform docking: AutoDock 4.2 made easy for non-bioinformaticians. Excil journal12(2013) 831–857.PMCID: PMC4669947.
19. O. Trott, A. J. Olson, AutoDockVina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading, Journal of Computational Chemistry 31 (2010) 455-461. DOI 10.1002/jcc.21334
20. Liang J, Edelsbrunner H, Woodward C. Anatomy of protein pockets and cavities: measurement of binding site geometry and implications for ligand design. Protein Sci. 1998;7:1884–1897. doi: 10.1002/pro.5560070905.
21. Y.W. Tan, M.J.Y. YanAng, Q.Y. Lau, A. Poulsen, F. M. Ng, S.W. Then, J. Peng, J. Hill, W.J. Hong, C.S. BrianChia, J.J.H. Chu, Antiviral activities of peptide based covalent inhibitors of the Enterovirus 71 3C protease. Scientific Reports 6 (2016) 1-8. DOI: 10.1038/srep33663.

Digital Economy and Its Collision of Black Money, Corruption and Demonetization
V. Muralidharan
Pages: 22-30 | First Published: 05 Sep 2022
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Abstract
In the present era, issue of BLACK MONEY has come into forefront of the society with active participation of our youth and parliament. At the stroke of the hour on midnight of 9th November 2016, India lost 86% of its monetary base. The electronic and social media has been praising Prime Minister’s masterstroke by which he has reportedly destroyed the base of corruption in India. In this single move, the Government has attempted to tackle all the three
issues affecting the economy i.e. a parallel economy, counterfeit currency in circulation and terror financing. Demonetization has brought a sense of justice among honest taxpayers and this would be further strengthened if the money recovered is used by the government efficiently and in a leak-proof manner for infrastructure development and social schemes.
Keywords: Black Money, Corruption, Demonetization Effect, Present Status, Future Challenges, and their effects.

1. Nafees.A.Khan, P.T.Chaudhary, "Black Money: Its Impact on the Indian Economy," Tax Reforms in India (Ed.), Srinawas Publications, Jaipur,pp. 150155,2003.
2. Sukanta Sarkar (2010). “The parallel economy in India: Causes, impacts & government initiatives ”.Economic Journal of Development Issues, Volume 11-12 no.(1-2) p.124- 134.
3. www.studymode.com/subjects/corrupti ons_and_black_money_page3.html
4. ^ a b Nanjappa, Vicky (31 March 2009). "Swiss black money can take India to the top". Rediff.com. Retrieved 23 May 2011.
5. ^ a b c d e f g h i j k l m n "White Paper on Black Money" (PDF). Ministry of Finance, Government of India. 2012.
6. ^ a b c "Banking secrecy spices up Indian elections". SWISSINFO - A member of Swiss Broadcasting Corporation. 14 May 2009.
7. ^ a b "Black money: Indians have stashed over $12 in banks abroad, says CBI". The Times of India. Retrieved 29 July 2015.
8. ^ Friedrich Schneider (September 2006). "Shadow Economies and Corruption All Over the World: What Do We Really Know?" (PDF). Institute for the Study of Labor (IZA Bonn).
9. ^ Owen Lippert, Michael Walker (December 1997). The Underground Economy: Global Evidence of Its Size and Impact. ISBN 978-0889751699.
10. ^ Frey and Schneider (2000). "Informal and Underground Economy" (PDF).
11. Black Money, Corruption and DemonetisationBY DR. MARTIN PATRICK · NOVEMBER 10, 201612. The Big Picture- Impact of DemonetizationBY INSIGHTS · NOVEMBER 16, 2016
13. Demonetization in India: Who Will Pay the Price?Nov 16, 2016.
14. Eradicate new black money after demonetisationN Sundaresha Subramanian | New Delhi Nov 19, 2016 01:44 PM IST
15. Rajni Arora (2012), “Black Money In India: Present Status And Future Challenges”.ISSN: 2278 – 7798 International Journal of Science, Engineering and Technology Research (IJSETR)Volume 1, Issue 5, November 2012.
16. www.google.com
17. www.msn.com
18. www.wikipedia.com

Brunt of Digitalization on the Banking Region
Dr. N. Anitha
Pages: 31-34 | First Published: 05 Sep 2022
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Abstract
“Digital” is the new buzz word in all sectors. With other sector, banking is also all around the globe shifting towards digitalization. Digitization is the conversion of data into a digital format with the adoption of technology. Adoption of digitalization is very important for the banking sector. By acceptance of digitalization, banks can provide enhanced customer services. This provides convenience to customers and helps in saving time. Digitalization reduces human error and thus builds customer loyalty. Today, people have round-the-clock access to banks due to online banking. Managing large amounts of cash has also become easier. Digitalization has also helped customers by facilitating cashless transactions. Customers need not store cash anymore and can make transactions at any place and time.
Keywords: Embracing, cashless, Digitalization…

1. Agrawal, S, „The Impact of Internet Banking in Thebanking Scenario‟, 12 (2015)
2. Boot A. (2016) ‘Understanding the Future of Banking Scale & Scope Economies, and FinTech’, University of Amsterdam, mimeo.
3. P.Ravilochan: Research methodology Margham Publications (2013)
4. Reserve Bank of India, „Handbook of Statistics on Indian States‟, 20175. Verdier M. and Mariotto R. (2015) ‘Innovation and Competition in Retail Banking’, Communications & Strategies, 98, pp. 129-145.