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Natural Acid Catalyzed Aqua Mediated multi component Synthesis of Tetrahydropyridines and its antioxidant Activities
Renu Sharma
Pages: 1-27 | First Published: 05 Apr 2022
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Abstract
Tetra hydropyridine derivatives are one of the most demanding molecules due to its great applications in medicinal and synthetic chemistry. Here we have designed a new way to synthesize a series of tetrahydropyridine derivatives using natural acid. In this methodology, five-component reaction of 1,3-diketones, substituted amines and aldehydes is done in the presence of citric acid extracted from lemon juice. High atom economy, green and mild conditions, high to moderate yields and shorter reaction times were the key features of this methodology. Later, we have discussed the antioxidant activities of our compounds. It is predicted that compound 2, 5, 11 and 12 were quite effective to show good antioxidant activity. 

Keywords: amines and aldehydes is done in the presence of citric acid extracted from lemon juice

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