Journal Issues

Abstract
Global Respiratory illness outbreak COVID-19 is a new public health crisis threatening humanity across the globe with the emergence and spread from central China in late 2019. The virus originated around Wuhan, Hubei province, China in December 2019 in bats and was transmitted through unknown intermediary sources to humans. The clinical presentation of viral infection ranges from asymptomatic to severe pneumonia with acute pulmonary distress syndrome is designated as COVID-19. WHO has characterized the disease as a pandemic due to its severity, as well as the shifting of epidemic zones across the globe from epicentre zone, China through a different stage of transmission by contact or inhalation with infected droplets and the incubation period, varies between 2 - 14 days. Treatment is essentially supportive; the effective role of antiviral agents is yet to be established and secondly without knowing the entire genome sequence of COVID- 19, no drug or vaccine can be effectively administered. Prevention entails home isolation of suspected cases and those with mild illnesses and strict infection control measures at hospitals that include contact and droplet precautions. The highest risk of healthcare-associated transmission is in the absence of standard precautions, when basic infection prevention and control measures for respiratory infections are not in place, and when handling patients where COVID infection is yet to be confirmed. The pandemic acceleration of COVID-19 indicates that the initial sporadic spreading worst hit the epicentre, China. But later on, epidemic zone shifts to nearly all continents. Several countries are experiencing sustained local transmission, including Europe and America at the end of February 2020. Current status indicates that confirmed and death cases pattern is rapidly varied among the different continents and emerged as an alarming health crisis of the Era in countries like Italy, Spain, U.K, Iran, and the USA. Although India is now in the 2nd stage of transmission and too far from the 3rd stage but till government has already taken deceive control measures. At the same time some of the Asian countries like South Korea, Japan has been reporting a slowdown in the growth of COVID-19 cases due to adoption concept of "Testing is central" to outbreak response that leads to early detection to minimizes further spread. The proportion of asymptomatic cases is currently unknown and hampers the realistic assessment of the virus epidemic potential andcomplicates the outbreak response. WHO has already announced a large global trial, called SOLIDARITY on 27th March 2020 which is focusing on the most promising panacea therapies including remdesivir; chloroquine and hydroxychloroquine; a combination of two HIV drugs, lopinavir, and ritonavir; and that same combination plus interferon-beta. The coronavirus (COVID-19) outbreak has already brought considerable human suffering and major economic disruption. Therefore in the current scenario, the exact global impact and extension of this new pandemic acceleration are yet uncertain.
Keywords: COVID-19, CoVs, WHO, personal protective equipment (PPE) and pandemic