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Microwave Assisted Rapid Biosynthesis and Anticancer Activity of Silver Oxide Nanoparticles

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Issue Abstract

Abstract
Silver oxide nanoparticles can be synthesized by chemical and biological methods. Biological synthesis emerges as an exciting, eco-friendly approach but the process is very slow given industrial applicability. The development of a reliable method for the rapid synthesis of nanoparticles is one of the significant interests in current nanotechnology research. In this paper, a combinatorial synthesis approach using microwave-assisted bioreduction of silver nitrate to silver oxide nanoparticles using Bacillus SSV1 culture supernatant is presented. Silver oxide nanoparticle synthesis was found to be rapid (<15 min) and spherical nanoparticles with an average particle size of 30 nm were obtained. The cytotoxic effect of the silver oxide nanoparticles was studied against
HepG2 and Chang liver cell lines by MTT assay. Silver oxide nanoparticles showed dose-dependent response on HepG2 (IC50= 0.47 μg/ml) and Chang liver cells (IC50=1.11μg/ml). This study proves to be an able alternative for rapid green synthesis of stable silver oxide nanoparticles to conventional methods.
Keywords: Silver oxide nanoparticle, Bacillus, Microwave, Anticancer, Cytotoxicity.

Author Information
Dr. VITHIYA K
Issue No
12
Volume No
2
Issue Publish Date
05 Dec 2016
Issue Pages
21-33

Issue References

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